RADIATION DOSE-VOLUME EFFECTS OF OPTIC NERVES AND CHIASM

被引：325
|
作者：
Mayo, Charles [1 ]
Martel, Mary K. [2 ]
Marks, Lawrence B. [3 ]
Flickinger, John [4 ]
Nam, Jiho [3 ]
Kirkpatrick, John [5 ]
机构：
[1] Univ Massachusetts, Mem Med Ctr, Dept Radiat Oncol, Sch Med, Worcester, MA 01655 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
[3] Univ N Carolina, Dept Radiat Oncol, Chapel Hill, NC USA
[4] Univ Pittsburgh, Presbyterian Hosp, Dept Radiat Oncol, Pittsburgh, PA 15213 USA
[5] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC USA
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2010年 / 76卷 / 03期
关键词：
Optic; Nerve; Chiasm; Tolerance; Radiotherapy; EXTERNAL-BEAM IRRADIATION; EFFECTS WORKING GROUP; PARANASAL SINUSES; SKULL-BASE; STEREOTACTIC RADIOSURGERY; PITUITARY-ADENOMAS; TOXICITY CRITERIA; CANCER-TREATMENT; CAVERNOUS SINUS; VISUAL PATHWAY;
D O I：
10.1016/j.ijrobp.2009.07.1753
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximate to 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined. (C) 2010 Elsevier Inc.
引用
收藏
页码：S28 / S35
页数：8
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