Is there any place for hypertonic saline for fluid resuscitation in septic shock?

被引：3

作者：

Libert, N. ^{[1
]}

de Rudnicki, S. ^{[1
]}

Cirodde, A. ^{[1
]}

Thepenier, C. ^{[2
]}

Mion, G. ^{[1
]}

机构：

[1] Hop Instruct Armees Val de Grace, Serv Reanimat, F-75005 Paris, France

[2] Ctr Transfus Sanguine Armees, Lab Rech, F-92141 Clamart, France

来源：

ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION | 2010年 / 29卷 / 01期

关键词：

Fluid loading; Hypertonic saline serum; Sepsis; Septic shock; ACUTE LUNG INJURY; PROTEIN-KINASE ACTIVATION; HEMORRHAGIC-SHOCK; HUMAN NEUTROPHILS; DEXTRAN RESUSCITATION; ORGAN DYSFUNCTION; VASCULAR-PERMEABILITY; BACTERIAL CHALLENGE; CARDIAC-FUNCTION; SEVERE SEPSIS;

D O I：

10.1016/j.annfar.2009.10.018

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Fluid loading is the first step, necessary to care for severe sepsis. Two main classes of solutions are currently available: crystalloids and colloids. The concept of small volume resuscitation with hypertonic saline has emerged these last years in the care of traumatic haemorrhagic shock. The main benefits are the restoration of intravascular volume, improvement of cardiac output and improvement of regional circulations. Many experiments highlight modulation of immune and inflammatory cascades. We report the mechanisms of action of hypertonic saline based on experimental human and animal studies, which advocate its use in septic shock. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：25 / 35

页数：11

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[1] RESUSCITATION FROM SEPTIC SHOCK WITH HYPERTONIC SALINE
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[2] Neurohypophyseal response to fluid resuscitation with hypertonic saline during septic shock in rats
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