Radiolysis of DNA-protein complexes

被引：8
|
作者：
Begusová, M
Gillard, N
Sy, D
Castaing, B
Charlier, M
Spotheim-Maurizot, M
机构：
[1] Inst Nucl Phys, Dept Radiat Dosimetry, CZ-18086 Prague 8, Czech Republic
[2] CNRS, Ctr Biophys Mol, F-45071 Orleans 2, France
来源：
RADIATION PHYSICS AND CHEMISTRY | 2005年 / 72卷 / 2-3期
关键词：
DNA radiolysis; protein radiolysis; lac operator-lac repressor complex; Fpg protein; abasic site;
D O I：
10.1016/j.radphyschem.2004.01.009
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We discuss here modifications of DNA and protein radiolysis due to the interaction of the-se two partners in specific complexes. Experimental patterns of frank strand breaks (FSB) and alkali revealed breaks (ARB) obtained for DNNA lac operator bound to the lac repressor and for a DNA containing an abasic site analog bound to the formamidopyrimidine-DNA glycosylase are reported. Experimental data are compared to predicted damage distribution obtained using the theoretical model RADACK. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：265 / 270
页数：6
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