Diastereoselective alkylations of oxazolidinone glycolates: A useful extension of the Evans asymmetric alkylation

被引：102
|
作者：
Crimmins, MT [1 ]
Emmitte, KA [1 ]
Katz, JD [1 ]
机构：
[1] Univ N Carolina, Venable & Kenan Labs Chem, Chapel Hill, NC 27599 USA
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 14期
关键词：
D O I：
10.1021/ol006091m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The diastereoselective alkylation of glycolate oxazolidinones has been demonstrated as a method for the enantioselective preparation of alpha-alkoxy carboxylic acid derivatives and selectively protected 1,2-diols, Various protecting groups on the glycolate hydroxyl and multiple substitution patterns on allylic iodides are tolerated in the alkylation, Yields for the alkylations are typically 70-85% with diastereoselectivities of >98:2.
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收藏
页码：2165 / 2167
页数：3
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