Hormesis: considerations and implications for human health risk assessment

被引：0
|
作者：
McKenna, EA [1 ]
机构：
[1] EA Engn Sci & Technol, Hunt Valley, MD 21031 USA
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENT AND POLLUTION | 1998年 / 9卷 / 01期
关键词：
dose-response; hormesis; linear multi-stage model; longevity; risk assessment; slope factor;
D O I：
暂无
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The concept of hormesis as a phenomenon is presented, in the context of its evolving definitions. Predominant types of hermetic effect and potential examples thereof are discussed, focusing on chemicals. The potential for hormesis to affect regulatory approaches and several basic processes used in formulating risk assessment parameters, such as study design, interpretation of dose-response information, and extrapolation of toxicity values, is examined. The potential ramifications for human health risk assessment and risk management an discussed.
引用
收藏
页码：90 / 107
页数：18
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