Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser

被引：12

作者：

Wang, Tai-Ang ^{[1
]}

Chan, Ming-Che ^{[1
]}

Lee, Hsiang-Chieh ^{[2
,3
]}

Lee, Cheng-Yu ^{[4
]}

Tsai, Meng-Tsan ^{[4
,5
]}

机构：

[1] Natl Chiao Tung Univ, Coll Photon, Inst Photon Syst, Tainan 71150, Taiwan

[2] Natl Taiwan Univ, Grad Inst Photon & Optoelect, Taipei 10617, Taiwan

[3] Natl Taiwan Univ, Dept Elect Engn, Taipei 10617, Taiwan

[4] Chang Gung Univ, Dept Elect Engn, Thoyuan 33302, Taiwan

[5] Chang Gung Mem Hosp, Dept Neurosurg, Taoyuan 33305, Taiwan

来源：

BIOMEDICAL OPTICS EXPRESS | 2019年 / 10卷 / 11期

关键词：

AXIAL RESOLUTION; DRUG-DELIVERY; TOMOGRAPHY; ANTERIOR; NOISE; FIBER;

D O I：

10.1364/BOE.10.005687

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, a Q-switch pumped supercontinuum laser (QS-SCL) is used as a light source for in vivo imaging via ultrahigh-resolution optical coherence tomography and angiography (UHR-OCT/OCTA). For this purpose, an OCT system based on a spectral-domain detection scheme is constructed, and a spectrometer with a spectral range of 635 - 875 nm is designed. The effective full-width at half maximum of spectrum covers 150 nm, and the corresponding axial and transverse resolutions are 2 and 10 mu m in air, respectively. The relative intensity noise of the QS-SCL and mode-locked SCL is quantitatively compared. Furthermore, a special processing algorithm is developed to eliminate the intrinsic noise of QS-SCL. This work demonstrates that QS-SCLs can effectively reduce the cost and size of UHR-OCT/OCTA instruments, making clinical applications feasible. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

引用

页码：5687 / 5702

页数：16

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