SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW Pt(IV) AND Ru(III) COMPLEXES OF FLUORENYLSPIROHYDANTOINS

被引：1
|
作者：
Marinova, Petja [1 ]
Marino, Marin [2 ,3 ]
Georgiev, Danail [2 ,3 ]
Becheva, Maria [4 ]
Penchev, Plamen [1 ]
Stoyanov, Neyko [5 ]
机构：
[1] Paisij Hilendarski Univ Plovdiv, Fac Chem, 24 Tzar Assen St, Plovdiv 4000, Bulgaria
[2] Paisij Hilendarski Univ Plovdiv, Fac Biol, 24 Tzar Assen St, Plovdiv 4000, Bulgaria
[3] Agr Univ Plovdiv, Fac Plant Protect & Agroecol, 12 Mendeleev Blvd, Plovdiv 4000, Bulgaria
[4] Med Univ Plovdiv, Med Coll Bulgaria, Plovdiv 4000, Bulgaria
[5] Univ Ruse, Dept Chem & Chem Technol, Razgrad Branch, 47 Aprilsko Vastanie Blvd, Razgrad 7200, Bulgaria
来源：
REVUE ROUMAINE DE CHIMIE | 2019年 / 64卷 / 07期
关键词：
(9 '-fluorene)-spiro-5-hydantoin; (9 '-fluorene)-spiro-5-(2-thiohydantoin); complex; antimicrobial effect; PLATINUM(II) COMPLEXES; RUTHENIUM COMPLEXES; CYTOTOXICITY; DERIVATIVES; COPPER(II);
D O I：
10.33224/rrch.2019.64.7.06
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The present work presents a synthesis, characterization and antimicrobial activitiy of new Pt(IV) and Ru(III) complexes of (9'-fluorene)-spiro-5-hydantoin (HL1) and (9'-fluorene)-spiro-5-(2-thiohydantoin) (HL2). The complexes were investigated by elemental analysis, UV-Vis and IR spectroscopy. The free ligands were studied by UV-Vis, IR, H-1 NMR, C-13 NMR and Raman spectroscopy. The antimicrobial tests of HL1 showed week bacteriostatic effect against Staphylococcus aureus ATCC 6538. The results for [Pt(L1)(2)(H2O)(2)(OH-)(2)] complex showed a good antimicrobial activity against Escherichia coli ATCC 8739, Bacillus licheniformis ATCC 6633, S. aureus and the absence of such effect on the yeasts. The HL2 and its [Pt(L2)(2)(H2O)(2)(OH-)(2)] and [Ru(L2)(3)(H2O)(3)] complexes do not possess antimicrobial activity against the tested bacteria and yeasts.
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收藏
页码：595 / 601
页数：7
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