Clinical and laboratory features and sequelae of deficiency of folic acid (folate) and vitamin B12 (cobalamin) in pregnancy and gynecology

被引:16
|
作者
Frenkel, EP
Yardley, DA
机构
[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Radiol, Dallas, TX 75390 USA
关键词
D O I
10.1016/S0889-8588(05)70172-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Classically, deficiency of folic acid (folate) or vitamin B-12 (cobalamin) was recognized by the presence of a macrocytic anemia resulting from megaloblastic changes in the bone marrow. A markedly changing paradigm has identified both new mechanisms for altered folate and cobalamin status and new sequelae and clinical interrelationships that include altered mechanisms of absorption, a changing pattern of neurologic deficits, an increased risk of vascular occlusive lesions, and an important relationship with the mechanisms of neoplastic transformation. Several of these newer characterizations relate to issues of neoplasia in the nonpregnant woman and to issues in pregnancy such as the potential for developmental abnormalities of the fetal nervous system.
引用
收藏
页码:1079 / +
页数:23
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