Telomerase and the aging process

被引：76
|
作者：
Hornsby, Peter J.
机构：
[1] Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78245 USA
[2] Univ Texas, Hlth Sci Ctr, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA
来源：
EXPERIMENTAL GERONTOLOGY | 2007年 / 42卷 / 07期
关键词：
telomerase; telomeres; senescence; cancer; immortalization;
D O I：
10.1016/j.exger.2007.03.007
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The level of telomerase activity is important in determining telomere length in aging cells and tissues. Here evidence on the importance of telomerase activity is reviewed with respect to aging rates of mammalian species and the health and life span of individuals within a species. The significance of telomerase reactivation for both cancer development and for immortalizing cells for therapeutic processes is assessed. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：575 / 581
页数：7
相关论文
共 50 条
  • [1] Telomerase and the cellular lifespan: Implications for the aging process
    Ostler, EL
    Wallis, CV
    Aboalchamat, B
    Faragher, RGA
    [J]. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2000, 13 : 1467 - 1476
  • [2] Downregulation of telomerase in rat during the aging process
    Kang, HK
    Kim, MS
    Kim, ND
    Yoo, MA
    Kim, KW
    Kim, J
    Ikeno, Y
    Yu, BP
    Chung, HY
    [J]. MOLECULES AND CELLS, 1999, 9 (03) : 286 - 291
  • [3] Epigenetics of telomerase inactivation as an early event of the aging process
    Tollefsbol, TO
    Poole, J
    Lopatina, N
    Saldanha, S
    Haskell, J
    Key, J
    Gray, J
    Desai, U
    Parikh, S
    Jones, W
    Andrews, L
    [J]. GERONTOLOGIST, 2001, 41 : 81 - 81
  • [4] Telomerase and Aging
    Li, Ying
    Huang, HongXing
    Wu, HuoYan
    [J]. 2012 INTERNATIONAL CONFERENCE ON EDUCATION REFORM AND MANAGEMENT INNOVATION (ERMI 2012), VOL 3, 2013, : 310 - 314
  • [5] TELOMERASE REVERSES AGING
    Chatterjee, Sreemoyee
    Agrawal, Shruti
    [J]. EVERYMANS SCIENCE, 2013, 47 (06): : 359 - 362
  • [6] Telomere, telomerase and aging
    Liu, Yie
    Bohr, Vilhelm A.
    Lansdorp, Peter
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2008, 129 (1-2) : 1 - 2
  • [7] Telomerase in cancer and aging
    Granger, MP
    Wright, WE
    Shay, JW
    [J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2002, 41 (01) : 29 - 40
  • [8] Telomerase, aging, and cancer
    Egorov, EE
    [J]. MOLECULAR BIOLOGY, 1997, 31 (01) : 10 - 17
  • [9] TELOMERASE, AGING, AND CANCER
    HARLEY, CB
    CHIU, CP
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 : S63 - S63
  • [10] Novel roles for telomerase in aging
    Geserick, Christoph
    Blasco, Maria A.
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2006, 127 (06) : 579 - 583
12345