Squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: synthesis and mechanism of action

被引：17

作者：

Quintana, Mireia ^{[1
]}

Alegre-Requena, Juan V. ^{[1
,2
]}

Marques-Lopez, Eugenia ^{[2
]}

Herrera, Raquel P. ^{[2
]}

Triola, Gemma ^{[1
]}

机构：

[1] CSIC, Inst Adv Chem Catalonia IQAC, Biomed Chem Dept, E-08034 Barcelona, Spain

[2] Univ Zaragoza, CSIC, Lab Organocatalisis Asimetr, Dept Quim Organ,ISQCH, E-50009 Zaragoza, Spain

来源：

MEDCHEMCOMM | 2016年 / 7卷 / 03期

关键词：

ENANTIOSELECTIVE MICHAEL ADDITION; BIOLOGICAL EVALUATION; KINASE INHIBITORS; APOPTOSIS; DEATH; DERIVATIVES; DISCOVERY; AUTOPHAGY; TOXICITY; POTENT;

D O I：

10.1039/c5md00515a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of squaramates and squaramides have been synthesized and their cytotoxic activity has been investigated in different cancer cell lines. Among the studied compounds, squaramide 34 showed a potent and selective cytotoxicity against the human gastric cancer cell line HGC-27. Studies directed to elucidate the mechanism of induced cell death were performed. Cell cycle distribution analysis and cell death studies showed that compound 34 induces cell cycle arrest at the G(1) phase and caspase-dependent apoptosis. In conclusion, squaramide 34 can be considered a potential anticancer agent for gastric carcinoma.

引用

页码：550 / 561

页数：12

共 50 条

[1] Endothelial transdifferentiation of human HGC-27 gastric cancer cells in vitro
Chen, Changxin
Hunag, Zhixin
Wang, Mucheng
Huang, Zicheng
Chen, Xiangbo
Huang, Anye
Zheng, Binbin
Wu, Lishan
Liu, Yi
Wang, Xinwen
Xu, Weifeng
ONCOLOGY LETTERS, 2020, 20 (06)
[2] A novel ratiometric fluorescent probe for the detection of hydrogen peroxide in human gastric carcinoma HGC-27 cells
Xie, Yong
Chen, Zhu
Hu, Linan
Zhang, Hailiang
Xu, Pengfei
Pan, Ke
ANALYTICAL METHODS, 2020, 12 (12) : 1567 - 1569
[3] In vitro sensitivity of human gastric cancer cells (HGC-27) to Helicobacter pylori cytotoxin
Pessina, A
Bayo, M
Croera, C
Meringolo, F
Neri, MG
Montesissa, L
Raimondi, A
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2003, 38 (12) : 1228 - 1234
[4] Effect of simulated microgravity on metabolism of HGC-27 gastric cancer cells
Chen, Zheng-Yang
Jiang, Nan
Guo, Song
Li, Bin-Bin
Yang, Jia-Qi
Chai, Shao-Bin
Yan, Hong-Feng
Sun, Pei-Ming
Zhang, Tao
Sun, Hong-Wei
Yang, He-Ming
Zhou, Jin-Lian
Cui, Yan
ONCOLOGY LETTERS, 2020, 19 (05) : 3439 - 3450
[5] A Preliminary Study of Side Population Cells in Human Gastric Cancer Cell Line HGC-27
Gao, Ganglong
Sun, Zhenliang
Liu Wenyong
Ye Dongxia
Zhao, Runjia
Zhang, Xueli
ANNALS OF TRANSPLANTATION, 2015, 20 : 147 - 153
[6] LOW CONCENTRATION OF BISPHENOL A INDUCES PROLIFERATION OF GASTRIC CANCER CELLS, HGC-27
Hanafi, Noorul Izzati
Kadir, Siti Hamimah Sheikh Abdul
Musa, Maslinda
Othman, Mohd Hafiz Dzarfan
Kamaludin, Roziana
Zulkifli, Nur Amira
Abd Latip, Normala
Karim, Zeti Rahayu A.
JURNAL TEKNOLOGI, 2019, 81 (06): : 115 - 121
[7] Inhibitory effect of 17β-estradiol on growth and the polyamine metabolism of a human gastric carcinoma cell line (HGC-27)
Messa, C
Pricci, M
Linsalata, M
Russo, F
Di Leo, A
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1999, 34 (01) : 79 - 84
[8] Effects of radioactive 125I on apoptosis of HGC-27 gastric cancer cells
Yang, Yong
Chen, Aifei
Ma, Jun
Wu, Aiping
Xu, Fazhen
ONCOLOGY LETTERS, 2019, 18 (05) : 4916 - 4922
[9] Physalin B inhibits cell proliferation and induces apoptosis in undifferentiated human gastric cancer HGC-27 cells
Fang, Chunsheng
Chen, Cunte
Yang, Yanjun
Li, Kehan
Gao, Rili
Xu, Dandan
Huang, Youxue
Chen, Zheng
Liu, Zhuandi
Chen, Shaohua
Yu, Xibao
Li, Yangqiu
Zeng, Chengwu
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2022, 18 (03) : 224 - 231
[10] Shikonin induces apoptosis in the human gastric cancer cells HGC-27 through mitochondria-mediated pathway
Hou, Yue
Xu, Jinghua
Liu, Xia
Xia, Xichun
Li, Ning
Bi, Xiuli
PHARMACOGNOSY MAGAZINE, 2015, 11 (42) : 250 - 256

← 1 2 3 4 5 →