A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis

被引：2
|
作者：
Michel, J [1 ]
Langstein, J [1 ]
Hofstädter, F [1 ]
Schwarz, H [1 ]
机构：
[1] Univ Regensburg, Dept Pathol, D-93042 Regensburg, Germany
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 1998年 / 28卷 / 01期
关键词：
rheumatoid arthritis; inflammation; cytokine receptor; human;
D O I：
10.1002/(SICI)1521-4141(199801)28:01<290::AID-IMMU290>3.3.CO;2-J
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD137 (ILA/4-1BB) is a member of the tumor necrosis factor receptor family and regulates activation, proliferation and programmed cell death in T lymphocytes. Here we show the existence of a soluble form of CD137 (sCD137) of 16 kDa. sCD137 is released by activated lymphocytes, and in contrast to membrane-bound CD137, expression of sCD137 seems to be restricted to lymphocytes, sCD137 is generated by alternative splicing and two splice variants were identified. sCD137 is present at low levels in sera of some healthy donors (5/12; mean = 0.18 ng/ml) and is significantly enhanced in sera of patients with rheumatoid arthritis (12/12; mean = 3.58 ng/ml).
引用
收藏
页码：290 / 295
页数：6
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