The spectrum of acute lymphoblastic leukemia with mature B-cell phenotype

被引：16
|
作者：
Chan, NPH
Ma, ESK
Wan, TSK
Chan, LC
机构：
[1] Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Div Hematol, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China
来源：
LEUKEMIA RESEARCH | 2003年 / 27卷 / 03期
关键词：
acute lymphoblastic leukemia; mature B-cell; morphology; immunophenotype; cytogenetics;
D O I：
10.1016/S0145-2126(02)00129-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We showed heterogeneous disease spectrum among 15 acute lymphoblastic leukemia (ALL) cases with mature B-cell phenotype diagnosed over the past 7 years at our institution. Besides those with typical L3 morphology and 8q24 (c-myc) translocation (n = 6), there were cases showing L1 or L2 morphology without 8q24 translocation (it = 6), unusually large L3 blasts in hyperdiploid clone (n = 2) and blastoid variant of mantle cell lymphoma (n = 1). The expression of CD5 and cyclin D I may need to be routinely determined on ALL cases with mature B-cell phenotype and non-L3 morphology to facilitate timely diagnosis of blastoid MCL and institution of suitable management. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：231 / 234
页数：4
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