First Detection of a Fosfomycin Resistance Gene, fosA7, in Salmonella enterica Serovar Heidelberg Isolated from Broiler Chickens

被引:1
|
作者
Rehman, Muhammad A. [1 ]
Yin, Xianhua [1 ]
Persaud-Lachhman, Marissa G. [1 ]
Diarra, Moussa S. [1 ]
机构
[1] Agr & Agri Food Canada, Guelph Res & Dev Ctr, Guelph, ON, Canada
关键词
fosfomycin resistance; fosA7; gene; Salmonella Heidelberg; broiler chicken; ESCHERICHIA-COLI; ENTEROBACTERIACEAE; IDENTIFICATION; PETS;
D O I
10.1128/AAC.00410-17
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We previously described Salmonella enterica serovar Heidelberg isolates harboring a chromosomal gene cluster similar to the glutathione S-transferase gene, a putative fosA gene conferring resistance to fosfomycin. Here, we show that this new gene, named fosA7, confers resistance to fosfomycin. The introduction of fosA7 into the fosfomycin-susceptible Salmonella enterica serovar Enteritidis resulted in a substantial increase in the fosfomycin MIC. This finding increases the awareness of antibiotic resistance in Salmonella Heidelberg from broilers as related to the food safety and public health.
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页数:6
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