Pentavalent technetium-99m-dimercaptosuccinic acid scintigraphy in renal osteodystrophy

Pentavalent Tc-99m-dimercaptosuccinic acid (DMSA) scintigraphy and Tc-99m-hydroxymethylene diphosphonate (HMDP) bone scan were performed in one patient with renal osteodystrophy (ROD) before and after vitamin D-3 pulse therapy, The bone scan showed diffusely increased tracer uptake in the whole skeleton, and no change of tracer distribution was noted before or after vitamin D-3 pulse therapy, However, (TC)-T-99m(V)-DMSA scintigraphy revealed diffusely increased tracer uptake in the whole skeleton before therapy, and markedly decreased tracer uptake in the bones was seen at 5 mo after therapy, Increased uptake of Tc-99m(V)-DMSA was observed at 7 mo after therapy, which reflected the laboratory findings, Technetium-99m-M-DMSA scintigraphy appeared to be more sensitive than the conventional Tc-99m-HMDP bone scan in assessing the characteristics and therapeutic effect of bone disease in ROD.