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Yale Univ, Sch Med, Dept Internal Med, Yale Cardiovasc Res Ctr,Sect Cardiovasc Med, 300 George St,Level 7, New Haven, CT 06511 USA Yale Univ, Sch Med, Dept Internal Med, Yale Cardiovasc Res Ctr,Sect Cardiovasc Med, 300 George St,Level 7, New Haven, CT 06511 USA