Novel Peptide from Spider Venom Inhibits P2X3 Receptors and Inflammatory Pain

被引：54

作者：

Grishin, Eugene V. ^{[1
]}

Savchenko, Ganna A. ^{[2
]}

Vassilevski, Alexander A. ^{[1
]}

Korolkova, Yuliya V. ^{[1
]}

Boychuk, Yaroslav A. ^{[2
]}

Viatchenko-Karpinski, Viacheslav Y. ^{[3
]}

Nadezhdin, Kirill D.

Arseniev, Alexander S.

Pluzhnikov, Kirill A. ^{[1
,4
]}

Kulyk, Vyacheslav B. ^{[2
,4
]}

Voitenko, Nana V. ^{[3
]}

Krishtal, Oleg O. ^{[2
]}

机构：

[1] Russian Acad Sci, Lab Neuroreceptors & Neuroregulators, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia

[2] Ukrainian Acad Sci, Dept Cellular Membranol, Bogomoletz Inst Physiol, Kiev, Ukraine

[3] Ukrainian Acad Sci, Dept Gen Physiol Nervous Syst, Bogomoletz Inst Physiol, Kiev, Ukraine

[4] Russian Acad Sci, Lab Biomol NMR Spect, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia

来源：

ANNALS OF NEUROLOGY | 2010年 / 67卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

P2X(3) RECEPTORS; SENSORY NEURONS; ANTAGONIST; CHANNELS; POTENT; RAT;

D O I：

10.1002/ana.21949

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

P2X3 purinoreceptors expressed in mammalian sensory neurons play a key role in several processes, including pain perception. From the venom of the Central Asian spider Geolycosa sp., we have isolated a novel peptide, named purotoxin-1 (PT1), which is to our knowledge the first natural molecule exerting powerful and selective inhibitory action on P2X3 receptors. PT1 dramatically slows down the removal of desensitization of these receptors. The peptide demonstrates potent antinociceptive properties in animal models of inflammatory pain. ANN NEUROL 2010;67:680-683

引用

页码：680 / 683

页数：4

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