One-step synthesis and pharmacological activity of new (N-substituted)amino-spiroalkan-dione derivatives

被引：0
|
作者：
Bonsignore, L
Loy, G
Cottiglia, F
Calignano, A
机构：
[1] Univ Cagliari, Dipartimento Farmaco Chim Tecnol, I-09124 Cagliari, Italy
[2] Univ Naples, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy
来源：
FARMACO | 1997年 / 52卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The synthesis of (N-substituted)amino-spiroalkan-dione derivatives 3 is described starting from enamines 1 and carbon suboxide 2, and their inhibitory effects on blood coagulation in vivo and on platelet aggregation in vitro are determined. Some of synthesized compounds showed a strong anticoagulant activity. A comparative pharmacological study of the anticoagulant effects of the new compounds versus Warfarin suggests that their behaviour is analogous, though the action mechanism is different.
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页码：663 / 666
页数：4
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