Myopia genetics in genome-wide association and post-genome-wide association study era

被引：2
|
作者：
Liao, Xuan [1 ,2 ]
Tan, Qing-Qing [1 ,2 ]
Lan, Chang-Jun [1 ,2 ]
机构：
[1] North Sichuan Med Coll, Dept Ophthalmol, Affiliated Hosp, Nanchong 637000, Sichuan, Peoples R China
[2] North Sichuan Med Coll, Dept Ophthalmol & Optometry, Nanchong 637000, Sichuan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY | 2019年 / 12卷 / 09期
关键词：
myopia; genetic variation; genome-wide association studies; omics; REFRACTIVE ERROR; SUSCEPTIBILITY LOCUS; RARE VARIANTS; AXIAL LENGTH; METAANALYSIS; REPLICATION; EXPRESSION; DISEASE; 15Q14; GWAS;
D O I：
10.18240/ijo.2019.09.18
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging. This review provides a brief summary of the main focus on the advantages and limitations of GWAS of myopia, with potential strategies that may contribute to further insight into the genetics of myopia in the post-GWAS or omits era.
引用
收藏
页码：1487 / 1492
页数：6
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