A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-Cell decay in vivo

被引：300
|
作者：
Markowitz, M
Louie, M
Hurley, A
Sun, E
Di Mascio, M
机构：
[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA
[2] Abbott Labs, Abbott Pk, IL 60064 USA
[3] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA
来源：
JOURNAL OF VIROLOGY | 2003年 / 77卷 / 08期
关键词：
D O I：
10.1128/JVI.77.8.5037-5038.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Mathematical models provide an understanding of in vivo replication kinetics of human immunodeficiency virus type 1 (HIV-1). With a novel intervention designed for increased potency, we have more accurately deduced the half-lives of virus-producing CD4+ T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication.
引用
收藏
页码：5037 / 5038
页数：2
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