Synthesis and characterization of chitosan nanoparticles modified by glycyrrhetinic acid as a liver targeting drug carrier

被引：0

作者：

Zha Rui-Tao

He Xiao-Ting

Du Tian

Yuan Zhi ^{[1
]}

机构：

[1] Nankai Univ, Inst Polymer Chem, Minist Educ, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China

[2] Tianjin Univ Sci & Technol, Coll Mat Sci & Chem Engn, Tianjin 300457, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2007年 / 28卷 / 06期

关键词：

glycyrrhetinic acid; chitosan; liver targeting;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chitosan derivative with glycyrrhetinic acid(GA), which was accumulated specifically in liver, was synthesized. By ion-crosslinking of TPP in GA-CTS solution, GA-CTS-TPP complex nanoparticles were obtained. The physicochemical properties of these nanoparticles were investigated by using TEM and DLS. The experiment in vitro BSA entrapped was studied. GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months.

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页码：1098 / 1100

页数：3