Peptidyl human heart chymase inhibitors.: 1.: Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P′ binding subsites

被引：28

作者：

Eda, M ^{[1
]}

Ashimori, A ^{[1
]}

Akahoshi, F ^{[1
]}

Yoshimura, T ^{[1
]}

Inoue, Y ^{[1
]}

Fukaya, C ^{[1
]}

Nakajima, M ^{[1
]}

Fukuyama, H ^{[1
]}

Imada, T ^{[1
]}

Nakamura, N ^{[1
]}

机构：

[1] Green Cross Res Labs, Dept Med Chem, Hirakata, Osaka 573, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(98)00131-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peptidyl difluoromethylene ketone derivatives were designed to take advantage of probable additional interactions with the S' subsite of human heart chymase. They showed potent inhibitory activities against human heart chymase and were more efficient than bovine chymotrypsin. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：913 / 918

页数：6

共 10 条

[1] Peptidyl human heart chymase inhibitors.: Part 1:: Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P′ binding subsites (vol 8, pg 913, 1998)
Eda, M
Ashimori, A
Akahoshi, F
Yoshimura, T
Inoue, Y
Fukaya, C
Nakajima, M
Fukuyama, H
Imada, T
Nakamura, N
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (13) : 1778 - 1778
[2] Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site
Eda, M
Ashimori, A
Akahoshi, F
Yoshimura, T
Inoue, Y
Fukaya, C
Nakajima, M
Fukuyama, H
Imada, T
Nakamura, N
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (08) : 919 - 924
[3] Peptidyl human heart chymase inhibitors. Part 2: Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site (vol 8, pg 919, 1998)
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Yoshimura, T
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