Multidrug-Resistant Gram-Negative Pathogens: The Urgent Need for 'Old' Polymyxins

被引：25
|
作者：
Paterson, David L. [1 ]
Bonomo, Robert A. [2 ]
机构：
[1] Univ Queensland, Clin Res Ctr, Brisbane, Qld, Australia
[2] Cleveland VA Med Ctr, Louis Stokes, Cleveland, OH USA
来源：
POLYMYXIN ANTIBIOTICS: FROM LABORATORY BENCH TO BEDSIDE | 2019年 / 1145卷
关键词：
Antibiotic resistance; Enterobacteriaceae; Acinetobacter baumannii; Pseudomonas aeruginosa; polymyxin; BETA-LACTAMASE; ACINETOBACTER-BAUMANNII; KLEBSIELLA-PNEUMONIAE; ENTEROBACTERIACEAE; PREVALENCE; STRAIN;
D O I：
10.1007/978-3-030-16373-0_2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Antibiotic resistance has presented a major health challenge in the world and many isolates of Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa become resistant to almost all current antibiotics. This chapter provides an overview on the mechanisms of antibiotic resistance in these Gram-negative pathogens and outlines the formidable problem of the genetics of bacterial resistance. Prevalent multidrug-resistance in Gram-negative bacteria underscores the need for optimizing the clinical use of the last-line polymyxins.
引用
收藏
页码：9 / 13
页数：5
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