Protein Nanoparticles Formed by Self-assembly of Human Serum Albumin with a Fatty Acid Arm

被引：3
|
作者：
Morita, Yoshitsugu [1 ]
Takahashi, Daiki [1 ]
Komatsu, Teruyuki [1 ]
机构：
[1] Chuo Univ, Fac Sci & Engn, Dept Appl Chem, Bunkyo Ku, 1-13-27 Kasuga, Tokyo 1128551, Japan
来源：
CHEMISTRY LETTERS | 2020年 / 49卷 / 01期
关键词：
Human serum albumin; Interprotein interaction; Molecular dynamics simulation; BINDING;
D O I：
10.1246/cl.190785
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the preparation of spherical protein nanoparticles comprising self-assembled human serum albumin (HSA) with an N-(11-carboxyundecyl)succinimido (CU) arm in aqueous medium at pH 5.0. Molecular dynamics simulation implied that the alternate CU chain bindings and multiple hydrogen bonds contribute the interprotein interaction. Cross-linking of the protein components by glutaraldehyde stabilized the particle under physiological pH.
引用
收藏
页码：103 / 106
页数：4
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