On initial ion velocities in MALDI: A novel FT-ICR MS approach

被引：10
|
作者：
Tomalova, Iva [1 ,2 ]
Frankevich, Vladimir [1 ]
Zenobi, Renato [1 ]
机构：
[1] ETH, Dept Chem & Appl Biosci, Zurich, Switzerland
[2] Masaryk Univ, Fac Sci, Dept Chem, CS-61137 Brno, Czech Republic
来源：
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2014年 / 372卷
关键词：
MALDI; Initial ion velocity; FT-ICR MS; ASSISTED LASER-DESORPTION; MATRIX; IONIZATION; TIME;
D O I：
10.1016/j.ijms.2014.08.004
中图分类号：
O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号：
070203 ; 070304 ; 081704 ; 1406 ;
摘要：
Even after more than two decades of investigation, the question whether the initial velocity of ions generated by matrix-assisted laser desorption/ionization (MALDI) depends on their molecular weight or not remains unanswered. A novel method employing an internal MALDI source Fourier-transform ion cyclotron resonance mass spectrometry is used to measure the initial ion velocities of peptides with m/z values in the range of typical proteomic experiments. Simultaneous measurement of multiple matrix and analyte ions clearly shows initial ion velocities that depend on analyte or matrix molecular weight. The measured velocity values agree well with the published data. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：51 / 53
页数：3
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