Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria

被引：31

作者：

Gruber, Jan ^{[1
,2
]}

Kennedy, Brian K. ^{[1
,3
,4
]}

机构：

[1] Natl Univ Singapore, Dept Biochem, Yong Loo Lin Sch Med, MD 7,8 Med Dr, Singapore 117596, Singapore

[2] Yale NUS Coll, Ageing Res Lab, Sci Div, Singapore 138527, Singapore

[3] Natl Univ Singapore, Dept Physiol, Yong Loo Lin Sch Med, MD 9,2 Med Dr, Singapore 117596, Singapore

[4] Buck Inst Res Aging, Novato, CA 94945 USA

来源：

CELL | 2017年 / 169卷 / 07期

关键词：

D O I：

10.1016/j.cell.2017.05.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microbiome has emerged as a major determinant of the functioning of host organisms, affecting both health and disease. Here, Han et al. use the workhorse of aging research, C. elegans, to identify specific mechanisms by which gut bacteria influence mitochondrial dynamics and aging, a first step toward analogous manipulations to modulate human aging.

引用

页码：1168 / 1169

页数：2

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