IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome

被引：45
|
作者：
Laron, Zvi [1 ]
Kauli, Rivka [1 ]
Lapkina, Lena [2 ]
Werner, Haim [2 ]
机构：
[1] Schneider Childrens Med Ctr, Endocrinol & Diabet Res Unit, Petah Tiqwa, Israel
[2] Tel Aviv Univ, Sackler Fac Med, Dept Human Mol Genet & Biochem, Tel Aviv, Israel
来源：
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2017年 / 772卷
基金：
以色列科学基金会;
关键词：
GROWTH-FACTOR-I; HORMONE RECEPTOR GENE; FAMILIAL DWARFISM; TREATED PATIENTS; INSENSITIVITY SYNDROME; PITUITARY DWARFISM; BODY-COMPOSITION; MOLECULAR-BASIS; FACTOR (IGF)-I; ADULT PATIENTS;
D O I：
10.1016/j.mrrev.2016.08.002
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：123 / 133
页数：11
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