HANG cancer vaccine rejects anti PD-1 therapy resistant-tumor via potent neoantigen-specific CTL in draining lymph node

被引：0
|
作者：
Momose, Fumiyasu [1 ]
Nakai, Takashi [2 ]
Shiraki, Koji [2 ]
Fukumoto, Keisuke [3 ]
Katsumata, Toru [3 ]
Yabuuchi, Kohei [3 ]
Muraoka, Daisuke [4 ]
Ikeda, Hiroaki [4 ]
Shiku, Hiroshi [1 ]
机构：
[1] Mie Univ, Grad Sch Med, Dept Personalized Canc Immunother, Tsu, Mie, Japan
[2] Chugai Pharm Co Ltd, Div Res, Tokyo, Japan
[3] Asahi Kasei Corp, Funct Addit Div, New Prod Dev Off, Tokyo, Japan
[4] Nagasaki Univ, Grad Sch Biomed Sci, Dept Oncol, Nagasaki, Japan
来源：
CANCER SCIENCE | 2022年 / 113卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
J12-2-5
引用
收藏
页数：1
相关论文
共 14 条
  • [1] Effective personalized neoantigen vaccine plus anti-PD-1 in a PD-1 blockade-resistant lung cancer patient
    Gao, Song
    Wang, Jiaqian
    Zhu, Zhongzheng
    Fang, Juemin
    Zhao, Yu
    Liu, Zhuqing
    Qin, Huanlong
    Wei, Yuquan
    Xu, Heng
    Dan, Xu
    Yang, Li
    Xu, Qing
    IMMUNOTHERAPY, 2023, 15 (02) : 57 - 70
  • [2] A tumor draining lymph node CD8 T cell memory response is pivotal for a decrease in recurrence after neoadjuvant anti PD-1 therapy for NSCLC
    Cruz, Tatiana Delgado
    Markowitz, Geoffrey J.
    Martin, Mitchell
    Singh, Arshdeep
    Bai, Shelley Yang
    Altorki, Nasser
    McGraw, Timothy
    Mittal, Vivek
    Villena-Vargas, Jonathan
    CANCER RESEARCH, 2023, 83 (07)
  • [3] Cancer immunotherapy with anti-PD-1 antibodies The unexpected role of interleukin 4 in the tumor-draining lymph node
    Guerin, Marion V.
    Ruggiu, Mathilde
    Bousso, Philippe
    M S-MEDECINE SCIENCES, 2024, 40 (8-9): : 613 - 615
  • [4] Tumor-draining lymph node-derived tumor-specific memory CD8+ T cells: a key player in PD-1/PD-L1 immunotherapy
    Yin, Enzhi
    Sun, Nan
    He, Jie
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8 (01)
  • [5] Tumor-draining lymph node-derived tumor-specific memory CD8+ T cells: a key player in PD-1/PD-L1 immunotherapy
    Enzhi Yin
    Nan Sun
    Jie He
    Signal Transduction and Targeted Therapy, 8
  • [6] Macrophage and T reg expression of PD-L1 in the tumor draining lymph node and not the primary tumor is associated with anti-PD-1 resistance in a model of metastatic triple negative breast cancer
    Quackenbush, Monika J.
    Lui, Asona
    Hollern, Daniel P.
    CANCER IMMUNOLOGY RESEARCH, 2025, 13 (02)
  • [7] DNA vaccine with PD-1 blockade elicits anti-tumor responses in patients with metastatic, castration-resistant prostate cancer (mCRPC)
    McNeel, Douglas
    Eickhoff, Jens
    Jeraj, Robert
    Staab, Mary Jane
    Straus, Jane
    Wargowski, Ellen
    Scarpelli, Matthew
    Liu, Glenn
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [8] Anti-PD-1 increases the clonality and activity of tumor infiltrating antigen specific T cells induced by a potent immune therapy consisting of vaccine and metronomic cyclophosphamide
    Weir, Genevieve M.
    Hrytsenko, Olga
    Quinton, Tara
    Berinstein, Neil L.
    Stanford, Marianne M.
    Mansour, Marc
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2016, 4
  • [9] Tumor-derived IL-8 facilitates lymph node metastasis of gastric cancer via PD-1 up-regulation in CD8+ T cells
    Xiang Li
    Jing Zhai
    Yuke Shen
    Tiancheng Zhang
    Yaohui Wang
    Yani He
    Qiang You
    Lizong Shen
    Cancer Immunology, Immunotherapy, 2022, 71 : 3057 - 3070
  • [10] Tumor-derived IL-8 facilitates lymph node metastasis of gastric cancer via PD-1 up-regulation in CD8+ T cells
    Li, Xiang
    Zhai, Jing
    Shen, Yuke
    Zhang, Tiancheng
    Wang, Yaohui
    He, Yani
    You, Qiang
    Shen, Lizong
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2022, 71 (12) : 3057 - 3070
12