The structure of Omeprazole in the solid state:: a 13C and 15N NMR/CPMAS study

被引:18
|
作者
Claramunt, Rosa M. [1 ]
Lopez, Concepcion [1 ]
Elguero, Jose [1 ]
机构
[1] Univ Nacl Educ Distancia, Fac Ciencias, Dept Quim Organ & Bioorgan, E-28040 Madrid, Spain
关键词
Omeprazole; NMR; C-13; N-15; CPMAS; tautomerism; benzimidazole;
D O I
10.3998/ark.5550190.0007.502
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The C-13 and N-15 CPMAS spectra of a solid sample of Omeprazole have been recorded and all the signals assigned. The sample consists uniquely of the 6-methoxy tautomer. For analytical purposes, the signals of the other tautomer, the 5-methoxy one, were estimated from the data in solution.
引用
收藏
页码:5 / 11
页数:7
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