Stereoselective synthesis of an advanced seco ester intermediate as a precursor toward the synthesis of amphidinolides T1, T3, and T4

被引：8
|
作者：
Sasmal, Pradip K. [1 ]
Abbineni, Chandrasekhar [1 ,2 ]
Iqbal, Javed [1 ,3 ]
Mukkanti, K. [2 ]
机构：
[1] Dr Reddys Labs Ltd, Discovery Res, Hyderabad 500049, Andhra Pradesh, India
[2] JNT Univ, Inst Sci & Technol, Div Chem, Hyderabad 500072, Andhra Pradesh, India
[3] Inst Life Sci, Hyderabad 500046, Andhra Pradesh, India
来源：
TETRAHEDRON | 2010年 / 66卷 / 27-28期
关键词：
Amphidinolide T family; Evan's aldol; Evan's alkylation; Oxy-Michael; Cross metathesis; CBS reduction; ENANTIOSELECTIVE SYNTHESIS; 19-MEMBERED MACROLIDE; DINOFLAGELLATE; ACID; COMPLEXES; ALCOHOLS; FRAGMENT; T2;
D O I：
10.1016/j.tet.2010.05.012
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, convergent, and stereoselective synthesis of a very advanced intermediate toward the total synthesis of amphidinolides T1, T3, and T4 utilising Evan's aldol and alkylation reactions, oxy-Michael, cross metathesis, stereoselective Grignard addition, and Yamaguchi esterification reactions as key steps is described. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5000 / 5007
页数：8
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