Melanoma models for the next generation of therapies

被引：109

作者：

Patton, E. Elizabeth ^{[1
,2
]}

Mueller, Kristen L. ^{[3
]}

Adams, David J. ^{[4
]}

Anandasabapathy, Niroshana ^{[5
]}

Aplin, Andrew E. ^{[6
]}

Bertolotto, Corine ^{[7
,51
]}

Bosenberg, Marcus ^{[8
,9
,10
]}

Ceo, Craig J. ^{[11
,12
]}

Burd, Christin E. ^{[13
,14
,15
]}

Chi, Ping ^{[16
,43
,52
,53
]}

Herlyn, Meenhard ^{[17
]}

Holmen, Sheri L. ^{[18
]}

Karreth, Florian A. ^{[19
]}

Kaufman, Charles K. ^{[20
]}

Khan, Shaheen ^{[21
]}

Kobold, Sebastian ^{[22
,23
,56
]}

Leucci, Eleonora ^{[24
,57
]}

Levy, Carmit ^{[25
]}

Lombard, David B. ^{[26
,27
]}

Lund, Amanda W. ^{[28
,29
]}

Marie, Kerrie L. ^{[30
]}

Marine, Jean-Christophe ^{[31
,54
]}

Marais, Richard ^{[32
]}

McMahon, Martin ^{[33
,34
]}

Robles-Espinoza, Carla Daniela ^{[35
,55
]}

Ronai, Ze'ev A. ^{[36
]}

Samuels, Yardena ^{[37
]}

Soengas, Maria S. ^{[38
]}

Villanueva, Jessie ^{[39
]}

Weeraratna, Ashani T. ^{[40
,41
]}

White, Richard M. ^{[42
,43
]}

Yeh, Iwei ^{[44
,45
]}

Zhu, Jiyue ^{[46
]}

Zon, Leonard, I ^{[47
,48
,49
]}

Hurlbert, Marc S. ^{[3
]}

Merlino, Glenn ^{[50
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Western Gen Hosp, MRC Inst Genet & Mol Med, Canc Res UK Edinburgh Ctr, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland

[3] Melanoma Res Alliance, 730 15th St NW, Washington, DC 20005 USA

[4] Wellcome Sanger Inst, Expt Canc Genet, Cambridge CB10 1SA, England

[5] Weill Cornell Med, Dept Dermatol, Meyer Canc Ctr, Program Immunol & Microbial Pathogenesis, New York, NY 10026 USA

[6] Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Dept Canc Biol, Philadelphia, PA 19107 USA

[7] Univ Cate dAzur, Nice, France

[8] Yale Univ, Dept Dermatol, New Haven, CT 06520 USA

[9] Yale Univ, Dept Pathol, New Haven, CT USA

[10] Yale Univ, Dept Immunobiol, New Haven, CT USA

[11] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA USA

[12] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, Worcester, MA USA

[13] Ohio State Univ, Dept Mol Genet, Biomed Res Tower,Room 918,460 W 12th Ave, Columbus, OH 43210 USA

[14] Ohio State Univ, Dept Canc Biol, Biomed Res Tower,Room 918,460 W 12th Ave, Columbus, OH 43210 USA

[15] Ohio State Univ, Dept Genet, Biomed Res Tower,Room 918,460 W 12th Ave, Columbus, OH 43210 USA

[16] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[17] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA

[18] Univ Utah, Hlth Sci Ctr, Huntsman Canc Inst, Dept Surg, Salt Lake City, UT 84112 USA

[19] H Lee Moffitt Canc Ctr & Res Inst, Dept Mol Oncol, Tampa, FL 33612 USA

[20] Washington Univ, Sch Med, Dept Med, Div Oncol,Dept Dev Biol, McDonnell Sci Bldg,4518 McKinley Ave, St Louis, MO 63110 USA

[21] UT Southwestern Med Ctr, Dept Pathol, Dallas, TX USA

[22] LMU, Klinikum Univ Munchen, Ctr Integrated Prot Sci Munich CIPS M, Munich, Germany

[23] LMU, Klinikum Univ Munchen, Dept Med 4, Div Clin Pharmacol, Munich, Germany

[24] Katholieke Univ Leuven, Lab RNA Canc Biol, Dept Oncol, LKI, B-3000 Leuven, Belgium

[25] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[26] Univ Michigan, Dept Pathol, Inst Gerontol, Ann Arbor, MI 48109 USA

[27] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[28] NYU, Grossman Sch Med, Ronald O Perelman Dept Dermatol, New York, NY 10016 USA

[29] NYU, Grossman Sch Med, Dept Pathol, New York, NY 10016 USA

[30] NCI, Lab Canc Biol & Genet, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[31] VIB, Lab Mol Canc Biol, Ctr Canc Biol, Leuven, Belgium

[32] Univ Manchester, CRUK Manchester Inst, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England

[33] Univ Utah, Dept Dermatol, Salt Lake City, UT USA

[34] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA

[35] Univ Nacl Autonoma Mexico, Lab Int Invest Genoma Humano, Campus Juriquilla,Blvd Juriquilla 3001, Santiago De Queretaro 76230, Mexico

[36] Sanford Burnham Med Discovery Inst, Canc Ctr, La Jolla, CA 92037 USA

[37] Weizmann Inst Sci, Dept Mol Cell Biol, Rehovot, Israel

[38] Spanish Natl Canc Res Ctr, Madrid 28029, Spain

[39] Wistar Inst Anat & Biol, Mol & Cellular Oncogenesis Program, 3601 Spruce St, Philadelphia, PA 19104 USA

[40] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA

[41] Johns Hopkins Sch Med, Sidney Kimmel Canc Ctr, Dept Oncol, Baltimore, MD 21205 USA

[42] Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, 1275 York Ave, New York, NY 10021 USA

[43] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[44] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA USA

[45] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[46] Washington State Univ, Coll Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Spokane, WA USA

[47] Harvard Univ, Boston Childrens Hosp, Stem Cell Program, Boston, MA 02115 USA

[48] Harvard Univ, Boston Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[49] Harvard Univ, Harvard Med Sch, Dana Farber Canc Inst, Howard Hughes Med Inst,Harvard Stem Cell Inst,Ste, Boston, MA 02115 USA

[50] NCI, Ctr Canc Res, NIH, 37 Convent Dr, Bethesda, MD 20892 USA

来源：

CANCER CELL | 2021年 / 39卷 / 05期

基金：

欧洲研究理事会; 美国国家卫生研究院; 欧盟地平线“2020”; 英国惠康基金;

关键词：

PATIENT-DERIVED XENOGRAFTS; BRAF INHIBITOR RESISTANCE; LONG-TERM SURVIVAL; MOUSE MODELS; NEURAL CREST; METASTATIC MELANOMA; MALIGNANT-MELANOMA; ANTITUMOR IMMUNITY; SOMATIC MUTATIONS; HUMAN TYROSINASE;

D O I：

10.1016/j.ccell.2021.01.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is a lack of appropriate melanoma models that can be used to evaluate the efficacy of novel therapeutic modalities. Here, we discuss the current state of the art of melanoma models including genetically engineered mouse, patient-derived xenograft, zebrafish, and ex vivo and in vitro models. We also identify five major challenges that can be addressed using such models, including metastasis and tumor dormancy, drug resistance, the melanoma immune response, and the impact of aging and environmental exposures on melanoma progression and drug resistance. Additionally, we discuss the opportunity for building models for rare subtypes of melanomas, which represent an unmet critical need. Finally, we identify key recommendations for melanoma models that may improve accuracy of preclinical testing and predict efficacy in clinical trials, to help usher in the next generation of melanoma therapies.

引用

页码：610 / 631

页数：22

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