Synthesis of some 5-amino-2-methyl-4-nitro-1-phenacylimidazoles

被引：0
|
作者：
Sobiak, S [1 ]
机构：
[1] K Marcinkowski Univ Med Sci, Fac Pharm, Dept Chem Technol Drugs, PL-60780 Poznan, Poland
来源：
POLISH JOURNAL OF CHEMISTRY | 1998年 / 72卷 / 01期
关键词：
nitroimidazoles; bromonitroimidazoles; aminonitroimidazoles; anticancer activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reaction of 4(5)-bromo-2-methyl-5(4)-nitroimidazole with phenacyl bromide derivatives gave two isomers: 4-bromo-5-nitroimidazoles (4a-e) and 5-bromo-4-nitroimidazoles (5a-e). Compounds 5a-e were treated with cyclic secondary amines to afford expected 5-amino-4-nitroimidazole derivatives 6a-c-10a-b.
引用
收藏
页码：78 / 83
页数：6
相关论文
共 50 条
  • [1] Azoles 48: Synthesis of some 4-amino-2-methyl-5-nitro-1-phenacylimidazoles
    Zaprutko, L
    Olender, D
    Gzella, A
    MONATSHEFTE FUR CHEMIE, 2003, 134 (08): : 1145 - 1150
  • [2] Azoles 48 [1]: Synthesis of Some 4-Amino-2-methyl-5-nitro-1-phenacylimidazoles
    Lucjusz Zaprutko
    Dorota Olender
    Andrzej Gzella
    Monatshefte für Chemie / Chemical Monthly, 2003, 134 : 1145 - 1150
  • [3] Isomerization of 4-bromo-2-methyl-5-nitro-1-phenacylimidazoles into 5-bromo-2-methyl-4-nitro-1-phenacylimidazoles
    Sobiak, S
    JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG, 1999, 341 (02): : 179 - 181
  • [4] Synthesis and results of our studies on structure-antitumor activity relationships of 5-amino-2-methyl-4nitro-1-phenacylimidazoles
    Sobiak, S
    Weidlich, I
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 23 : S37 - S37
  • [5] Synthesis of 4-[2'-(5'-nitro) imidazolyl] benzoyl (N-methyl) amino acids and peptides
    Das, Paramita
    Lal, V. K.
    Saxena, Vikas
    Himaja, M.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2007, 17 (01) : 71 - 74
  • [6] AMIDOSULFONES AND AMINOSULFONES .26. SYNTHESIS OF SOME DERIVATIVES OF 2-METHYL-5-NITRO AND 4-METHYL-3-NITRO-BENZENESULFONIC ACIDS
    FELDMAN, IK
    MIKHAILOVA, VN
    JOURNAL OF GENERAL CHEMISTRY USSR, 1963, 33 (01): : 33 - &
  • [7] Synthesis and characterization of 4-amino-5-nitro-1, 2, 3-trazole
    Xi'an Modern Chemistry Research Institute, Xi'an 710065, China
    Hanneng Cailiao, 2008, 1 (49-52):
  • [8] Synthesis of 2-amino-5-(1-methyl-5-nitro-[4-3H]-2-imidazolyl)-1,3,4- thiadiazole
    Grp. de Chimie Organique Biologique, UMR 5623, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse, France
    不详
    J. Label. Compd. Radiopharm., 1 (47-51):
  • [9] Synthesis of 2-amino-5-(1-methyl-5-nitro-[4-3H]-2-imidazolyl)-1,3,4-thiadiazole
    Chauviere, G
    Rousseau, B
    Pillon, F
    Perie, J
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1998, 41 (01): : 47 - 51
  • [10] Synthesis of 2-methyl-4(5)-nitro[15N1(3)]imidazole from 2-methyl-4(5)-nitroimidazole
    Suwński, Jerzy
    Szczepankiewicz, Wojciech
    Journal of Labelled Compounds and Radiopharmaceuticals, 1996, 38 (04): : 395 - 401
12345