Advances in neonatal screening for primary immune deficiencies

被引：4

作者：

Jiang, Tingting ^{[1
]}

Li, Zhenguang ^{[1
]}

Zhang, Qiuli ^{[1
]}

机构：

[1] Xuzhou Childrens Hosp, Dept Neonatol, 18 Sudibei Rd, Xuzhou 221002, Jiangsu, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2016年 / 11卷 / 05期

关键词：

primary immunodeficiencies; neonate screening; immune competence; SEVERE COMBINED IMMUNODEFICIENCY; COMMON VARIABLE IMMUNODEFICIENCY; IDENTIFICATION; ANTIBODIES; THERAPY; SYSTEM;

D O I：

10.3892/etm.2016.3119

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The congenital disorders of immune competence are known as primary immunodeficiencies (PID) and are mainly characterized by a pathological susceptibility to infection. These infections are mostly of time repetitive and drug resistant in nature. The number of infected infants has reached over 200 and is on the increase. Additionally, clinical severity of the disease has been confirmed to be extensive. The increasing number of these severe PIDs is due to the lack of specific as well as efficient management avenues. New assays and concepts for newborn screening of severe primary immune deficiencies are being explored and the present review focused on these new upcoming strategies for improved screening of neonates.

引用

页码：1542 / 1544

页数：3

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