Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans

被引：186
|
作者：
Klepser, ME
Wolfe, EJ
Jones, RN
Nightingale, CH
Pfaller, MA
机构：
[1] UNIV IOWA HOSP & CLIN,DEPT PATHOL,IOWA CITY,IA 52242
[2] HARTFORD HOSP,RES OFF,HARTFORD,CT 06102
[3] UNIV CONNECTICUT,SCH PHARM,STORRS,CT 06268
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 06期
关键词：
D O I：
10.1128/AAC.41.6.1392
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Time-kill curves mere determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIG. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.
引用
收藏
页码：1392 / 1395
页数：4
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