The use of spirocyclic scaffolds in drug discovery

被引：835

作者：

Zheng, Yajun ^{[1
]}

Tice, Colin M. ^{[1
]}

Singh, Suresh B. ^{[1
]}

机构：

[1] Vitae Pharmaceut Inc, Ft Washington, PA 19034 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 16期

关键词：

Spirocyclic; Scaffold; Drug discovery; 1; BACE1; INHIBITORS; MACROCYCLIC INHIBITORS; UREA DERIVATIVES; RECEPTOR LIGANDS; INVERSE AGONISTS; POTENT; DESIGN; OPTIMIZATION; BETA; IDENTIFICATION;

D O I：

10.1016/j.bmcl.2014.06.081

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review, we highlight selected examples from the primary medicinal chemistry literature during the last three years to demonstrate the versatility of spiro scaffolds. With recent progress in synthetic methods providing access to spiro building blocks, spiro scaffolds are likely to be used more frequently in drug discovery. (C) 2014 The Authors. Published by Elsevier Ltd.

引用

页码：3673 / 3682

页数：10

共 50 条

[1] Spirocyclic scaffolds in drug discovery
Tice, Colin
Zheng, Yajun
Singh, Suresh
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
[2] The utilization of spirocyclic scaffolds in novel drug discovery
Zheng, Ya-Jun
Tice, Colin M.
EXPERT OPINION ON DRUG DISCOVERY, 2016, 11 (09) : 831 - 834
[3] Recent in vivo advances of spirocyclic scaffolds for drug discovery
Batista, Vasco F.
Pinto, Diana C. G. A.
Silva, Artur M. S.
EXPERT OPINION ON DRUG DISCOVERY, 2022, 17 (06) : 603 - 618
[4] Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery
Geary, Gemma C.
Nortcliffe, Andrew
Pearce, Christopher A.
Hamza, Daniel
Jones, Geraint
Moody, Christopher J.
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (04) : 791 - 797
[5] Have spirocyclic scaffolds been properly utilized in recent drug discovery efforts?
Benedetti, Erica
Micouin, Laurent
EXPERT OPINION ON DRUG DISCOVERY, 2024, 19 (03) : 263 - 266
[6] Indoloquinolines as Scaffolds for Drug Discovery
Lavrado, J.
Moreira, R.
Paulo, A.
CURRENT MEDICINAL CHEMISTRY, 2010, 17 (22) : 2348 - 2370
[7] Carbohydrates as scaffolds in drug discovery
Meutermans, Wirn
Le, Giang Thanh
Becker, Bernd
CHEMMEDCHEM, 2006, 1 (11) : 1164 - 1194
[8] Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery
Kirichok, Alexander A.
Shton, Irina O.
Pishel, Irina M.
Zozulya, Sergey A.
Borysko, Petro O.
Kubyshkin, Vladimir
Zaporozhets, Olha A.
Tolmachev, Andrei A.
Mykhailiuk, Pavel K.
CHEMISTRY-A EUROPEAN JOURNAL, 2018, 24 (21) : 5444 - 5449
[9] Synthesis of oxetanes as scaffolds for drug discovery
Bull, James A.
Davis, Owen A.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
[10] New heterocyclic scaffolds for drug discovery
Winograd, Lexie
Wang, Yufei
Stevens, Erland P.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248

← 1 2 3 4 5 →