BRCA1: exploring the links to transcription

被引：76
|
作者：
Monteiro, ANA [1 ]
机构：
[1] Cornell Univ, Weill Med Coll, Dept Cell Biol, New York, NY 10021 USA
[2] Strang Canc Prevent Ctr, Oncol Mol Lab, New York, NY 10021 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 10期
关键词：
D O I：
10.1016/S0968-0004(00)01632-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Progress on determining the function of the breast and ovarian cancer susceptibility gene BRCA1 suggests it might be involved in two fundamental cellular processes: DNA repair and transcriptional regulation. Recent developments indicate that BRCA1 is a multifunctional protein, and disruption of its transcriptional activity could be crucial for tumor development.
引用
收藏
页码：469 / 474
页数：6
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