The role of RNA interference in heterochromatic silencing

被引：397
|
作者：
Lippman, Z
Martienssen, R
机构：
[1] Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
NATURE | 2004年 / 431卷 / 7006期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
D O I：
10.1038/nature02875
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Soon after its discovery 75 years ago, heterochromatin, a dense chromosomal material, was found to silence genes. But its importance in regulating gene expression was controversial. Long thought to be inert, heterochromatin is now known to give rise to small RNAs, which, by means of RNA interference, direct the modification of proteins and DNA in heterochromatic repeats and transposable elements. Heterochromatin has thus emerged as a key factor in epigenetic regulation of gene expression, chromosome behaviour and evolution.
引用
收藏
页码：364 / 370
页数：7
相关论文
共 50 条
  • [1] The role of RNA interference in heterochromatic silencing
    Zachary Lippman
    Rob Martienssen
    Nature, 2004, 431 : 364 - 370
  • [2] Slicing and spreading of heterochromatic silencing by RNA interference
    Locke, S. M.
    Martienssen, R. A.
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2006, 71 : 497 - 503
  • [3] Slicing and Spreading of Heterochromatic Silencing by RNA Interference
    Locke, S. M.
    Martienssen, R. A.
    REGULATORY RNAS, 2006, 71 : 497 - 503
  • [4] Accumulation of RNA on chromatin disrupts heterochromatic silencing
    Broenner, Cornelia
    Salvi, Luca
    Zocco, Manuel
    Ugolini, Ilaria
    Halic, Mario
    GENOME RESEARCH, 2017, 27 (07) : 1174 - 1183
  • [5] Intra- and intercellular RNA interference in Arabidopsis thaliana requires components of the microRNA and heterochromatic silencing pathways
    Dunoyer, Patrice
    Himber, Christophe
    Ruiz-Ferrer, Virginia
    Alioua, Abdelmalek
    Voinnet, Olivier
    NATURE GENETICS, 2007, 39 (07) : 848 - 856
  • [6] Intra- and intercellular RNA interference in Arabidopsis thaliana requires components of the microRNA and heterochromatic silencing pathways
    Patrice Dunoyer
    Christophe Himber
    Virginia Ruiz-Ferrer
    Abdelmalek Alioua
    Olivier Voinnet
    Nature Genetics, 2007, 39 : 848 - 856
  • [7] Heterochromatic Gene Silencing by Activator Interference and a Transcription Elongation Barrier
    Johnson, Aaron
    Wu, Ronghu
    Peetz, Matthew
    Gygi, Steven P.
    Moazed, Danesh
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (40) : 28771 - 28782
  • [8] Silent running: RNA interference and heterochromatic modification
    Martienssen, Rob
    Zaratiegui, Mikel
    Irvine, Danielle
    Goto, Derek
    Slotkin, Keith
    Tanurdzic, Milos
    Lippman, Zach
    Vaughn, Matt
    May, Bruce
    Cande, Zac
    Colot, Vincent
    Doerge, R. W.
    CHROMOSOME RESEARCH, 2007, 15 : 20 - 21
  • [9] Silencing viruses by RNA interference
    Colbère-Garapin, F
    Blondel, B
    Saulnier, A
    Pelletier, I
    Labadie, K
    MICROBES AND INFECTION, 2005, 7 (04) : 767 - 775
  • [10] RNA interference - Silencing the sceptics
    Jones, D
    NATURE REVIEWS GENETICS, 2004, 5 (12) : 887 - 887
12345