Serum 25-Hydroxyvitamin D Levels: Related to Ambulatory Arterial Stiffness Index in Hypertensive Seniors

Background: This study aims to explore the relation between 25(OH)D level, ambulatory arterial stiffness index (AASI), and other parameters from ambulatory blood pressure monitoring (ABPM). Methods: The study sample consisted of 102 older patients with essential hypertension. Clinical characteristics of population divided into three groups according to 25(OH)D tertile. Results: The patients in the high tertile of 25(OH)D with low body mass index (BMI) (P < 0.01), low tertile group with high low-density lipoprotein (LDL) (P < 0.05). Significant differences were in terms of Office SBP, Office PP, 24 h SBP, 24 h PP, daytime SBP, daytime PP, night-time SBP, night-time PP (P < 0.01), nocturnal dipping (P < 0.05) and ASSI (P < 0.01) among three groups. AASI showed decrease as 25(OH)D increases. Differences are significant. Correlation test showed a significant relationship of AASI with BMI (r = 0.368, P < 0.001), 24 h average SBP (r = 0.641, P < 0.001), 24 h average PP (0.66, P < 0.001), nocturnal dipping (r = -0.217, P < 0.05), 25(OH)D (r = -0.621, P < 0.001). Multivariate liner regression analysis showed that 25(OH)D (P < 0.01) and 24 h average PP (P < 0.01) were independently related to AASI. Conclusions: The relationship of AASI with BMI, 24 h average SBP, 24 h average PP, Nocturnal dipping, 25(OH)D are significant. 25(OH)D (P < 0.01) and 24 h average PP (P < 0.01) were independently related to AASI. Copyright (C) 2018, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC.