Macrocyclic antibiotics as chiral selectors in the design of enantioselective, potentiometric membrane electrodes

被引：2

作者：

Rat'ko, AA

Stefan, RI ^{[1
]}

van Staden, JF

Aboul-Enein, HY

机构：

[1] Univ Pretoria, Dept Chem, ZA-0002 Pretoria, South Africa

[2] King Faisal Specialist Hosp & Res Ctr, Biol & Med Res Dept MBC 03 65, Pharmaceut Anal & Drug Dev Lab, Riyadh 11211, Saudi Arabia

来源：

INSTRUMENTATION SCIENCE & TECHNOLOGY | 2004年 / 32卷 / 06期

关键词：

enantioselective potentiometric membrane electrode; vancomycin; teicoplanin; acetyl-L-carnitine;

D O I：

10.1081/CI-200037017

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two enantioselective, potentiometric membrane electrodes, based on macrocyclic Glycopeptide antibiotics-vancomycin and teicoplanin-were designed. Acetyl-L-carnitine was selected as model analyte. The linear concentration ranges for the proposed electrodes were 10(-5)-10(-2) mol L-1 for the vancomycin-based electrode and 10(-4)-10(-2) mol L-1 for the teicoplanin-based electrode, with slopes of 58.1 and 55.0 mV/p (acetyl-L-carnitine), respectively. The enantioselectivity was determined over D-carnitine. The surfaces of the electrodes are easily renewable by polishing on alumina paper.

引用

页码：601 / 610

页数：10

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