Oncofertility care for newly diagnosed girls with cancer in a national pediatric oncology setting, the first full year experience from the Princess Maxima Center, the PEARL study

被引：20

作者：

van der Perk, M. E. Madeleine ^{[1
]}

van der Kooi, Anne-Lotte L. F. ^{[2
]}

van de Wetering, Marianne D. ^{[1
]}

IJgosse, Irene M. ^{[1
]}

van Dulmen-den Broeder, Eline ^{[1
]}

Broer, Simone L. ^{[3
]}

Klijn, Aart J. ^{[4
]}

Versluys, A. Birgitta ^{[1
]}

Arends, Brigitte ^{[3
]}

Ophuis, Ralph J. A. Oude ^{[3
]}

van Santen, Hanneke M. ^{[1
,5
]}

van der Steeg, Alida F. W. ^{[1
]}

Veening, Margreet A. ^{[1
]}

Van den Heuvel-Eibrink, Marry M. ^{[1
]}

Bos, Annelies M. E. ^{[3
]}

机构：

[1] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

[2] Erasmus MC, Dept Obstet & Gynecol, Univ Med Ctr Rotterdam, Rotterdam, Netherlands

[3] Univ Med Ctr Utrecht, Reprod Med & Gynecol, Utrecht, Netherlands

[4] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Pediat Urol, Utrecht, Netherlands

[5] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Pediat Endocrinol, Utrecht, Netherlands

来源：

PLOS ONE | 2021年 / 16卷 / 03期

关键词：

QUALITY-OF-LIFE; FERTILITY PRESERVATION; CHILDHOOD-CANCER; PANCARELIFE CONSORTIUM; GENETIC-VARIATION; AMERICAN-SOCIETY; GONADAL-FUNCTION; OVARIAN RESERVE; SURVIVORS; ADOLESCENT;

D O I：

10.1371/journal.pone.0246344

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Childhood cancer patients often remain uninformed regarding their potential risk of gonadal damage. In our hospital we introduced a five step standard oncofertility care plan for all newly diagnosed female patients aiming to identify, inform and triage 100% of patients and counsel 100% of patients at high risk (HR) of gonadal damage. This observational retrospective study (PEARL study) evaluated the use of this standard oncofertility care plan in the first full year in a national cohort. Methods The steps consist of 1)timely (preferably before start of gonadotoxic treatment) identification of all new patients, 2)triage of gonadal damage risk using a standardized gonadal damage risk stratification tool, 3)informing all patients and families, 4)counseling of a selected subset of girls, and 5) fertility preservation including ovarian tissue cryopreservation (OTC) in HR patients using amended Edinburgh criteria. A survey of the medical records of all girls newly diagnosed with cancer the first year (1-1-2019 until 31-12-2019) was conducted. Results Of 261 girls, 228 (87.4%) were timely identified and triaged. Triage resulted in 151 (66%) low(LR), 32 (14%) intermediate(IR) and 45 (20%) high risk(HR) patients. Ninety-nine families were documented to be timely informed regarding gonadal damage risk. In total, 35 girls (5 LR, 5 IR, 25 HR) were counseled by an oncofertility expert. 16/25 HR patients underwent fertility preservation (1 ovariopexy + OTC, oocyte cryopreservation (1 with and 1 without OTC) and 13 OTC). Fertility preservation did not lead to complications or delay of cancer treatment in any patient. Conclusion We timely identified and triaged most girls (88%) with cancer with a high risk of gonadal damage to be counseled for fertility preservation. We aim to optimize the oncofertility care plan and the standardized gonadal damage risk stratification tool based on this experience and these may be of value to other pediatric oncology centers.

引用

页数：18

共 1 条

[1] Onco-Fertility Care for Newly Diagnosed Girls With Cancer in a National Pediatric Oncology Setting, The First Experiences From the Princess Maxima Center, The Pearl Study
Van der Perk, M. E. M.
Van der Kooi, A. -L.
Van de Wetering, M. D.
Ijgosse, I. M.
Van Dulmen-Den Broeder, E.
Broer, S. L.
Veening, M. A.
Klijn, A. J.
Versluys, A. B.
Arends, B.
Ophuis, R. J. A. Oude
Van Santen, H. M.
Van der Steeg, A. F. W.
Van den Heuvel-Eibrink, M. M.
Bos, A. M. E.
PEDIATRIC BLOOD & CANCER, 2020, 67 : S30 - S31

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