Antiproliferative Activity of Withanolides against Human Breast Cancer Cell Lines

被引：47

作者：

Machin, Ruben P.

Veleiro, Adriana S. ^{[2
,3
]}

Nicotra, Viviana E. ^{[4
,5
]}

Oberti, Juan C. ^{[4
,5
]}

Padron, Jose M. ^{[1
]}

机构：

[1] Univ La Laguna, BioLab, IUBO AG, San Cristobal la Laguna 38206, Spain

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Ciencias Exactas & Nat, CONICET, UMYMFOR, Buenos Aires, DF, Argentina

[4] Univ Nacl Cordoba, Dept Quim Organ, Fac Ciencias Quim, RA-5000 Cordoba, Argentina

[5] Univ Nacl Cordoba, IMBIV, Fac Ciencias Quim, RA-5000 Cordoba, Argentina

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 05期

关键词：

D O I：

10.1021/np9006734

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 mu M. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.

引用

页码：966 / 968

页数：3

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