Dual inhibition of PI3Kdelta and PI3Kgamma to enhance mitochondrial mass and ex vivo expansion of central and stem cell memory T cells from CLL patients

被引：0

作者：

Funk, Christopher ^{[1
]}

Wang, Shuhua ^{[1
]}

Waller, Alexandra ^{[1
]}

Fleischer, Lauren ^{[1
]}

Sharma, Aditi ^{[1
]}

Spencer, Harold ^{[1
]}

Gupta, Vikas ^{[1
]}

Ravindranathan, Sruthi ^{[1
]}

Shanmugam, Mala ^{[1
]}

Flowers, Christopher ^{[1
]}

Waller, Edmund ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Atlanta, GA USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2019年 / 7卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

P178

引用

页数：2

共 7 条

[1] Simultaneous Inhibition of PI3Kgamma and PI3Kdelta Deteriorates T- cell Function With Implications for Chronic Lymphocytic Leukemia
Faehling, Sebastian
ONCOLOGY RESEARCH AND TREATMENT, 2024, 47 : 117 - 117
[2] Simultaneous Inhibition of PI3Kgamma and PI3Kdelta Deteriorates T-cell Function With Implications for Chronic Lymphocytic Leukemia
Faehling, Sebastian
Coelho, Mariana
Floerchinger, Alessia
Schneider, Christof
Stilgenbauer, Stephan
Lichter, Peter
Seiffert, Martina
Roessner, Philipp M.
HEMASPHERE, 2023, 7 (03): : E840
[3] Dual Inhibition of PI3K Delta and PI3K Gamma Isoforms to Prevent Graft-Versus-Host Disease By Limiting T Cell Expansion In Vivo
Wang, Shuhua
Passang, Tenzin
Li, Yiwen
Zhang, Hanwen
Das, Pankoj Kumar
Chen, Kevin
Funk, Christopher R.
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[4] Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition
Abu Eid, Rasha
Ahmad, Shamim
Lin, Yuan
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Shrimali, Rajeev
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Ananth, Sudha
Rodriguez, Paulo C.
Celis, Esteban
Janik, John
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Khleif, Samir N.
CANCER RESEARCH, 2017, 77 (15) : 4135 - 4145
[5] Manufacturing an Enhanced CAR T Cell Product By Inhibition of the PI3K/Akt Pathway During T Cell Expansion Results in Improved In Vivo Efficacy of Anti-BCMA CAR T Cells
Perkins, Molly R.
Grande, Shannon
Hamel, Amanda
Horton, Holly M.
Garrett, Tracy E.
Miller, Sara M.
Latimer, Howard J.
Horvath, Christopher J.
Kuczewski, Michael
Friedman, Kevin M.
Morgan, Richard A.
BLOOD, 2015, 126 (23)
[6] Dual Inhibition of PI3K-Delta and Gamma By Duvelisib (IPI-145) Impairs CLL B- and T-Cell Migration, Survival and Proliferation in a Murine Xenograft Model Using Primary Chronic Lymphocytic Leukemia Cells
Chen, Shih-Shih
Ham, Steven
Rai, Kanti R.
McGovern, Karen
Kutok, Jeffery L.
Chiorazzi, Nicholas
BLOOD, 2015, 126 (23)
[7] Either IL-7 activation of JAK-STAT or BEZ inhibition of PI3K-AKT-mTOR pathways dominates the single-cell phosphosignature of ex vivo treated pediatric T-cell acute lymphoblastic leukemia cells
Kuzilkova, Daniela
Bugarin, Cristina
Rejlova, Katerina
Schulz, Axel R.
Mei, Henrik E.
Paganin, Maddalena
Biffi, Alessandra
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Kalina, Tomas
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HAEMATOLOGICA, 2022, 107 (06) : 1293 - 1310

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