Chilblains in immune-mediated inflammatory diseases: a review

被引：8
|
作者：
Dubey, Shirish [1 ,2 ]
Joshi, Nilay [3 ]
Stevenson, Olivia [3 ]
Gordon, Caroline [4 ]
Reynolds, John A. [5 ,6 ]
机构：
[1] Univ Oxford, Dept Rheumatol, Oxford Univ Hosp NHS FT, Oxford, England
[2] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England
[3] Kettering Gen Hosp NHS FT, Dept Rheumatol, Kettering, England
[4] Univ Birmingham, Rheumatol Res Grp, Inst Inflammat & Ageing IIA, Birmingham, W Midlands, England
[5] Univ Birmingham, John A Reynolds Rheumatol Res Grp, Inst Inflammat & Ageing IIA, Birmingham, W Midlands, England
[6] Sandwell & West Birmingham NHS Trust, Rheumatol Dept, Birmingham, W Midlands, England
来源：
RHEUMATOLOGY | 2022年 / 61卷 / 12期
关键词：
Chilblains; chilblain lupus erythematosus; CHLE; immune-mediated inflammatory diseases; IMID; LUPUS-ERYTHEMATOSUS HUTCHINSON; AICARDI-GOUTIERES SYNDROME; CLINICAL CHARACTERISTICS; PERNIOSIS; NIFEDIPINE; EFFICACY; PLACEBO; MANIFESTATION; ASSOCIATION; ANTIBODIES;
D O I：
10.1093/rheumatology/keac231
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chilblains were first described over a hundred years ago as cutaneous inflammatory lesions, typically on the digits, occurring on cold exposure. Chilblains can be primary, or secondary to a number of conditions such as infections, including COVID-19, and immune-mediated inflammatory disorders (IMIDs) with SLE being the commonest. Chilblain lupus erythematosus (CHLE) was first described in 1888 as cold-induced erythematous lesions before the terms 'chilblains' or 'perniosis' were coined. Diagnostic criteria exist for both chilblains and CHLE. Histopathologically, CHLE lesions show interface dermatitis with perivascular lymphocytic infiltrate. Immunofluorescence demonstrates linear deposits of immunoglobulins and complement in the dermo-epidermal junction. This narrative review focuses on chilblains secondary to immune-mediated inflammatory disorders, primarily the epidemiology, pathogenesis and treatment of CHLE.
引用
收藏
页码：4631 / 4642
页数：12
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