Label-free Electrochemical Detection of ATP Based on Amino-functionalized Metal-organic Framework

被引：49
|
作者：
Shi, Pengfei [1 ]
Zhang, Yuanchao [2 ]
Yu, Zhaopeng [1 ]
Zhang, Shusheng [1 ]
机构：
[1] Linyi Univ, Shandong Prov Key Lab Detect Technol Tumor Makers, Coll Chem & Chem Engn, Linyi 276000, Peoples R China
[2] Qufu Normal Univ, Shandong Prov Key Lab Life Organ Anal, Coll Chem & Chem Engn, Qufu 273165, Peoples R China
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
基金：
中国国家自然科学基金;
关键词：
SIGNAL AMPLIFICATION; SENSITIVE DETECTION; GRAPHENE OXIDE; APTASENSOR; NANOPARTICLES; BIOSENSOR; DESIGN; SENSOR; PROBE; ACID;
D O I：
10.1038/s41598-017-06858-w
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A sensitive, selective and recyclable electrochemical sensor is designed for ATP detection based on amino-functionalized metal-organic framework. The functional MOF as the sensor is constructed by one-step synthesis Ce-MOF and sequentially modified on the Au electrode and conjugated with the aptamer of ATP. The presence of target ATP leads to the conformational change of aptamer strands and strong electrochemical impedance. The electrochemical sensor can detect ATP down to 5.6 nM with the linear range of 10 nm to 1000 mu M. The present study is the first report on the use of MOF as an electrochemical sensor for ATP at nM level. This strategy has been successfully applied in detection of ATP in serum of cancer patients, which reveals its potential application in clinical diagnosis.
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页数：7
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