Lung Volume and Ventilation Inhomogeneity in Preterm Infants at 15-18 Months Corrected Age

被引:29
|
作者
Schulzke, Sven M. [1 ,3 ]
Hall, Graham L. [2 ,4 ]
Nathan, Elizabeth A. [5 ]
Simmer, Karen [1 ,2 ,3 ]
Nolan, Gary [2 ,4 ]
Pillow, J. Jane [1 ]
机构
[1] Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia
[2] Univ Western Australia, Sch Paediat & Child Hlth, Perth, WA 6009, Australia
[3] Princess Margaret & King Edward Mem Hosp, Dept Neonatal Paediat, Perth, WA, Australia
[4] Princess Margaret & King Edward Mem Hosp, Dept Resp Med, Perth, WA, Australia
[5] King Edward Mem Hosp, Women & Infants Res Fdn, Perth, WA, Australia
来源
JOURNAL OF PEDIATRICS | 2010年 / 156卷 / 04期
关键词
FUNCTIONAL RESIDUAL CAPACITY; ULTRASONIC FLOW METER; MULTIPLE-BREATH WASHOUT; CYSTIC-FIBROSIS; PULMONARY-FUNCTION; RESPIRATORY-FUNCTION; HEALTHY INFANTS; AIRWAY FUNCTION; FUNCTION TESTS; DISEASE;
D O I
10.1016/j.jpeds.2009.10.017
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To assess whether lung volume and ventilation inhomogeneity in preterm infants at 15-18 months corrected age, and the change in these outcomes from the newborn period to 15-18 months corrected age, depend on gestational age (GA) at birth and the severity of neonatal lung disease. Study design Preterm (GA range, 23-32 weeks) and term healthy control infants were studied in quiet sedated sleep at 15-18 months corrected age by multiple breath washout with 5% sulfur hexafluoride using an ultrasonic flowmeter. Valid measurements were obtained from 58 infants. Multivariate and multilevel regression was used to analyze outcomes. Results Functional residual capacity (FRC), lung clearance index, and first and second to zeroeth moment ratios were calculated. After accounting for body size at test, FRC at follow-up, and the increase in FRC from the newborn period to 15-18 months corrected age were positively associated with GA and negatively associated with the duration of endotracheal ventilation. Indices of ventilation inhomogeneity were unaltered by GA and the duration of endotracheal ventilation. Conclusions In very preterm infants, GA and the duration of endotracheal ventilation are independently associated with reduced lung volume and lung growth during infancy, although the effect size of these findings is small. (J Pediatr 2010; 156: 542-9).
引用
收藏
页码:542 / U61
页数:10
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