Review Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation

被引：23
|
作者：
Sommerkamp, Pia [1 ,2 ,3 ]
Cabezas-Wallscheid, Nina [4 ]
Trumpp, Andreas [1 ,2 ,3 ,5 ,6 ]
机构：
[1] German Canc Res Ctr, Div Stem Cells & Canc, D-69120 Heidelberg, Germany
[2] DKFZ ZMBH Alliance, D-69120 Heidelberg, Germany
[3] Heidelberg Inst Stem Cell Technol & Expt Med HI S, D-69120 Heidelberg, Germany
[4] Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany
[5] Heidelberg Univ, Fac Biosci, D-69117 Heidelberg, Germany
[6] German Canc Consortium DKTK, D-69120 Heidelberg, Germany
来源：
TRENDS IN MOLECULAR MEDICINE | 2021年 / 27卷 / 07期
基金：
欧洲研究理事会;
关键词：
PRE-MESSENGER-RNA; CLEAVAGE FACTOR-I; 3' UNTRANSLATED REGIONS; REGENERATIVE MEDICINE; 3'-END CLEAVAGE; GENE-EXPRESSION; C-MYC; PROTEIN; SIGNAL; MECHANISMS;
D O I：
10.1016/j.molmed.2021.04.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3 '- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA stability, output, and protein isoform expression. Cell-state-dependent 3 '-UTR shortening has been identified as a hallmark of cellular proliferation. Hence, quiescent/dormant stem cells are characterized by long 3 '-UTRs, whereas proliferative stem/progenitor cells exhibit 3 '-UTR shortening. Here, the latest studies analyzing the role of APA in regulating stem cell state, self-renewal, differentiation, and metabolism are reviewed. The new role of APA in controlling stem cell fate opens novel potential therapeutic avenues in the field of regenerative medicine.
引用
收藏
页码：660 / 672
页数：13
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