Lung cancer. Developments, concepts and preview of the new WHO classification

被引：0
|
作者：
Petersen, I. [1 ]
Warth, A. [2 ]
机构：
[1] Univ Klinikum Jena, Inst Pathol, D-07743 Jena, Germany
[2] Univ Klinikum Heidelberg, Inst Pathol, Heidelberg, Germany
来源：
PATHOLOGE | 2014年 / 35卷 / 06期
关键词：
Pulmonary neoplasms; Diagnosis; Classification; Immunohistochemistry; Molecular pathology; RESPIRATORY SOCIETY CLASSIFICATION; GIANT-CELL CARCINOMA; INTERNATIONAL ASSOCIATION; IASLC/ATS/ERS CLASSIFICATION; PULMONARY ADENOCARCINOMAS; RHABDOID PHENOTYPE; INTEROBSERVER; MUTATIONS; PROGNOSIS; DIAGNOSIS;
D O I：
10.1007/s00292-014-1915-1
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The diagnostics of pulmonary neoplasms has considerably changed in recent years. Based on large-scale molecular characterization studies and the development of targeted therapies, precise morphological, immunohistochemical and molecular pathological tumor subtyping is now of utmost importance for evidence-based treatment decisions. This review highlights recent developments in morphological and immunohistochemical subtyping of pulmonary neoplasms, concepts of tumor progression and provides a preview of relevant changes of the forthcoming new WHO classification, which is expected to be published in 2015. It becomes apparent that a 3-step diagnostic procedure based on morphology, immunohistochemistry and molecular pathology is important to meet the requirements of an increasingly more complex, interdisciplinary care of lung cancer patients and to allow reliable, clinically meaningful tumor diagnosis.
引用
收藏
页码：547 / 556
页数：10
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