Delayed Haematological recovery after autologous stem cell transplantation is associated with favourable outcome in acute myeloid leukaemia

被引：16
|
作者：
Wetzel, Dana [1 ,2 ]
Mueller, Beatrice U. [2 ,3 ]
Taleghani, Behrouz Mansouri [2 ,4 ]
Baerlocher, Gabriela M. [2 ,4 ]
Seipel, Katja [2 ,3 ]
Leibundgut, Kurt [2 ,5 ]
Pabst, Thomas [1 ,2 ]
机构：
[1] Univ Hosp Bern, Dept Med Oncol, CH-3010 Bern, Switzerland
[2] Univ Bern, Bern, Switzerland
[3] Univ Hosp Bern, Dept Clin Res, CH-3010 Bern, Switzerland
[4] Univ Hosp Bern, Dept Haematol, CH-3010 Bern, Switzerland
[5] Univ Hosp Bern, Dept Paediat Haematooncol, CH-3010 Bern, Switzerland
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2015年 / 168卷 / 02期
基金：
瑞士国家科学基金会;
关键词：
autologous transplant; acute myeloid leukaemia; recovery; prognosis; stem cell; BONE-MARROW-TRANSPLANTATION; 1ST COMPLETE REMISSION; PERIPHERAL-BLOOD; INTENSIVE CHEMOTHERAPY; ENGRAFTMENT; METAANALYSIS; RELAPSE; TRIALS; ADULTS;
D O I：
10.1111/bjh.13118
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autologous stem cell transplantation (ASCT) is applied to consolidate first remission in patients with acute myeloid leukaemia (AML). However, outcome after ASCT widely varies among AML patients. We analyzed the prognostic significance of haematological recovery for neutrophils [absolute neutrophil count (ANC) >10x10(9)/l] and platelets (platelet count >200x10(9)/l), stratifying at day 20 after ASCT in 88 consecutive and homogeneously treated AML patients in first remission. We observed that patients with delayed recovery had better overall survival (OS; ANC: P<00001 and platelets: P=00062) and time to progression (TTP; ANC: P=00003 and platelets: P=00125). Delayed recovery was an independent marker for better OS and TTP in a multivariate analysis including age, gender, number of transfused CD34+ cells, cytogenetics, FLT3-internal tandem duplication and NPM1 mutation. Our results suggest that delayed neutrophil and platelet recovery is associated with longer OS and TTP in AML patients consolidated with ASCT in first remission.
引用
收藏
页码：268 / 273
页数：6
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