Lymphangiogenesis - New mechanisms

被引:50
|
作者
Chang, L
Kaipainen, A
Folkman, J
机构
[1] Childrens Hosp, Surg Res Lab, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA
关键词
angiogenesis; lymphangiogenesis; bFGF; VEGF-A; VEGF-D; angiogenesis inhibitor; lymph angiogenesis inhibitor; lymphatic endothelial cells; blood vessel endothelial cells; murine cornea neovascularization;
D O I
10.1111/j.1749-6632.2002.tb04872.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A mouse model has been developed to study lymphangiogenesis dissociated from angiogenesis. bFGF implanted in a mouse cornea at a concentration below the threshold to induce angiogenesis potently induces lymphangiogenesis. This model has permitted a study of cellular and molecular mechanisms of lymphangiogenesis.
引用
收藏
页码:111 / 119
页数:9
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