ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up

被引：212

作者：

Honecker, F. ^{[1
,2
]}

Aparicio, J. ^{[3
]}

Berney, D. ^{[4
]}

Beyer, J. ^{[5
]}

Bokemeyer, C. ^{[2
]}

Cathomas, R. ^{[6
]}

Clarke, N. ^{[7
]}

Cohn-Cedermark, G. ^{[8
,9
]}

Daugaard, G. ^{[10
]}

Dieckmann, K-P. ^{[11
]}

Fizazi, K. ^{[12
]}

Fossa, S. ^{[13
]}

Germa-Lluch, J. R. ^{[14
]}

Giannatempo, P. ^{[15
]}

Gietema, J. A. ^{[16
]}

Gillessen, S. ^{[17
,18
]}

Haugnes, H. S. ^{[19
,20
]}

Heidenreich, A. ^{[21
]}

Hemminki, K. ^{[22
]}

Huddart, R. ^{[23
]}

Jewett, M. A. S. ^{[24
,25
]}

Joly, F. ^{[26
]}

Lauritsen, J. ^{[10
]}

Lorch, A. ^{[27
]}

Necchi, A. ^{[15
]}

Nicolai, N. ^{[28
]}

Oing, C. ^{[2
]}

Oldenburg, J. ^{[29
]}

Ondrus, D. ^{[30
]}

Papachristofilou, A. ^{[31
]}

Powles, T. ^{[32
]}

Sohaib, A. ^{[33
]}

Stahl, O. ^{[34
]}

Tandstad, T. ^{[35
]}

Toner, G. ^{[36
,37
]}

Horwich, A. ^{[38
]}

机构：

[1] Tumor & Breast Ctr ZeTuP, St Gallen, Switzerland

[2] Univ Med Ctr, Hematol & Bone Marrow Transplantat, Dept Oncol, Hubertus Wald Tumorzentrum,Sect Pneumol, Hamburg, Germany

[3] Hosp Univ & Politecn la Fe, Dept Med Oncol, Valencia, Spain

[4] Queen Mary Univ London, Barts Canc Inst, Dept Mol Oncol, London, England

[5] Univ Bern, Univ Hosp Bern, Dept Med Oncol, Inselspital, Bern, Switzerland

[6] Kantonsspital Graubunden, Dept Hematol & Oncol, Chur, Switzerland

[7] Christie NHS Fdn Trust, Dept Surg, Manchester, Lancs, England

[8] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden

[9] Karolinska Univ Hosp, Stockholm, Sweden

[10] Rigshosp, Copenhagen Univ Hosp, Dept Oncol, Copenhagen, Denmark

[11] Asklepios Klin Altona, Dept Urol, Hamburg, Germany

[12] Univ Paris Sud, Dept Canc Med, Gustave Roussy, Villejuif, France

[13] Radiumhosp, Dept Oncol, Oslo Univ Hosp, Oslo, Norway

[14] Barcelona Univ, ICO, Dept Med Oncol, Barcelona, Spain

[15] Fdn IRCCS Ist Tumori, Dept Med Oncol, Milan, Italy

[16] Univ Med Ctr Groningen, Dept Med Oncol, Groningen, Netherlands

[17] Kantonsspital St Gallen, Dept Oncol & Hematol, St Gallen, Switzerland

[18] Univ Bern, Bern, Switzerland

[19] Univ Hosp North Norway, Dept Oncol, Tromso, Norway

[20] UIT, Inst Clin Med, Tromso, Norway

[21] Univ Cologne, Dept Urol, Urooncol, Robot Assisted & Specialised Urol Surg, Cologne, Germany

[22] German Canc Res Ctr, Dept Mol Genet Epidemiol, Heidelberg, Germany

[23] Royal Marsden Hosp, Inst Canc Res, Dept Radiotherapy & Imaging, Sutton, Surrey, England

[24] Univ Toronto, Univ Hlth Network, Princess Margaret Canc Ctr, Dept Surg Urol, Toronto, ON, Canada

[25] Univ Toronto, Univ Hlth Network, Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON, Canada

[26] Ctr Francois Baclesse, Dept Urol Gynaecol, Caen, France

[27] Heinrich Heine Univ Hosp Dusseldorf, Dept Urol, Genitourinary Med Oncol, Dusseldorf, Germany

[28] Fdn IRCCS Ist Tumori, Urol & Testis Surg Unit, Dept Surg, Milan, Italy

[29] Akershus Univ Hosp, Dept Oncol, Lorenskog, Norway

[30] Comenius Univ, St Elisabeth Canc Inst, Dept Oncol 1, Fac Med, Bratislava, Slovakia

[31] Univ Hosp Basel, Dept Radiat Oncol, Basel, Switzerland

[32] Queen Mary Univ London, Barts Canc Inst, Dept Med Oncol, London, England

[33] Royal Marsden Hosp, Dept Radiol, Sutton, Surrey, England

[34] Lund Univ, Skane Univ Hosp, Dept Oncol, Lund, Sweden

[35] St Olavs Hosp, Canc Clin, Trondheim, Norway

[36] Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic, Australia

[37] Univ Melbourne, Melbourne, Vic, Australia

[38] Royal Marsden Hosp, Inst Canc Res, Sutton, Surrey, England

来源：

ANNALS OF ONCOLOGY | 2018年 / 29卷 / 08期

关键词：

testicular germ cell cancer; consensus; diagnosis; treatment; quality of life; follow-up; STAGE-I SEMINOMA; LYMPH-NODE DISSECTION; HIGH-DOSE CHEMOTHERAPY; MEDICAL-RESEARCH-COUNCIL; SINGLE-AGENT CARBOPLATIN; POSITRON-EMISSION-TOMOGRAPHY; CISPLATIN-BASED CHEMOTHERAPY; RANDOMIZED PHASE-III; INTRAEPITHELIAL NEOPLASIA TIN; LARGE INTERNATIONAL DATABASE;

D O I：

10.1093/annonc/mdy217

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The European Society for Medical Oncology (ESMO) consensus conference on testicular cancer was held on 3-5 November 2016 in Paris, France. The conference included a multidisciplinary panel of 36 leading experts in the diagnosis and treatment of testicular cancer (34 panel members attended the conference; an additional two panel members [CB and K-PD] participated in all preparatory work and subsequent manuscript development). The aim of the conference was to develop detailed recommendations on topics relating to testicular cancer that are not covered in detail in the current ESMO Clinical Practice Guidelines (CPGs) and where the available level of evidence is insufficient. The main topics identified for discussion related to: (1) diagnostic work-up and patient assessment; (2) stage I disease; (3) stage II-III disease; (4) post-chemotherapy surgery, salvage chemotherapy, salvage and desperation surgery and special topics; and (5) survivorship and follow-up schemes. The experts addressed questions relating to one of the five topics within five working groups. Relevant scientific literature was reviewed in advance. Recommendations were developed by the working groups and then presented to the entire panel. A consensus vote was obtained following whole-panel discussions, and the consensus recommendations were then further developed in post-meeting discussions in written form. This manuscript presents the results of the expert panel discussions, including the consensus recommendations and a summary of evidence supporting each recommendation. All participants approved the final manuscript.

引用

页码：1658 / 1686

页数：29

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