Current role of selective internal radiation with yttrium-90 in liver tumors

被引：17

作者：

Lau, Wan Yee ^{[1
]}

Teoh, Yee Leong ^{[2
]}

Win, Khin Maung ^{[3
]}

Lee, Rheun-Chuan ^{[4
,5
]}

de Villa, Vanessa H. ^{[6
,7
]}

Kim, Yun Hwan Joseph ^{[8
]}

Liang, Po-Chin ^{[9
]}

Santos-Ocampo, Ramon S. ^{[10
]}

Lo, Richard Hoau Gong ^{[11
]}

Lim, Kieron Boon Leng ^{[12
]}

Tai, David Wai Meng ^{[13
]}

Ng, David Chee Eng ^{[14
]}

Irani, Farah Gillan ^{[11
]}

Gogna, Apoorva ^{[11
]}

Chow, Pierce Kah-Hoe ^{[15
,16
]}

机构：

[1] Chinese Univ Hong Kong, Fac Med, Shatin, Hong Kong, Peoples R China

[2] Singapore Clin Res Inst, Singapore, Singapore

[3] Univ Med 1, Dept Hepatol, Minist Hlth, Yangon, Myanmar

[4] Natl Yang Ming Univ Taipei, Taipei Vet Gen Hosp, Dept Radiol, Taipei, Taiwan

[5] Natl Yang Ming Univ Taipei, Sch Med, Taipei, Taiwan

[6] Med City, Dept Surg, Pasig, Metro Manila, Philippines

[7] Med City, Ctr Liver Dis Management & Transplantat, Pasig, Metro Manila, Philippines

[8] Korea Univ, Dept Radiol, Anam Hosp, Seoul, South Korea

[9] Natl Taiwan Univ Hosp, Dept Med Imaging, Taipei, Taiwan

[10] Makati Med Ctr, Dept Radiol, Makati, Philippines

[11] Singapore Gen Hosp, Dept Diagnost Radiol, Singapore, Singapore

[12] Natl Univ Singapore Hosp, Div Gastroenterol & Hepatol, Natl Univ Ctr Organ Transplantat, Singapore 117548, Singapore

[13] Natl Canc Ctr, Div Med Oncol, Singapore, Singapore

[14] Singapore Gen Hosp, Dept Nucl Med & PET, Singapore, Singapore

[15] Natl Canc Ctr Singapore, Dept Surg Oncol, Singapore 169610, Singapore

[16] Duke NUS Grad Med Sch, Off Clin Sci, Singapore, Singapore

来源：

FUTURE ONCOLOGY | 2016年 / 12卷 / 09期

关键词：

UNRESECTABLE HEPATOCELLULAR-CARCINOMA; CLINICAL-PRACTICE GUIDELINES; MICROSPHERE RADIOEMBOLIZATION; NEUROENDOCRINE TUMORS; TREATING PATIENTS; YOUNGER PATIENTS; YTTRIUM; 90; METASTASES; SAFETY; SURVIVAL;

D O I：

10.2217/fon-2016-0035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An expert panel met to review the evidence for selective internal radiation therapy (SIRT) using yttrium-90 microspheres in hepatocellular carcinoma and metastases from colorectal cancer and neuroendocrine tumors. There is now convincing evidence for the safety and efficacy of SIRT in these situations albeit mostly from retrospective cohort studies. There are a number of ongoing prospective randomized controlled clinical trials investigating the role of SIRT in liver tumors; however, data from these trials are still several years away (although the SIRFLOX study has been recently published). In this evolving environment, published evidence and the authors' experience were used to summarize the current and potential role of SIRT in the management of hepatocellular carcinoma of intermediate or advanced stage and in liver-dominant metastatic colorectal cancer and metastatic neuroendocrine tumors.

引用

页码：1193 / 1204

页数：12

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